The Twin Cities sit on fairly gentle terrain, so the drives here follow rivers and lakes rather than mountains. The main ones follow the Mississippi bluffs along Lake Pepin, the St. Croix valley, and Lake Superior's North Shore beyond Duluth.

River road along the Wisconsin shore of Lake Pepin, under the bluffs.
Wisconsin Highway 35 runs as the Great River Road from Prescott, at the mouth of the St. Croix, south through Diamond Bluff, Bay City, Maiden Rock and Stockholm. It follows Lake Pepin, 22 miles long, past Pepin and Nelson to Alma.
Best time to go: Open year round. Check 511 Wisconsin road conditions in winter.

Sources: Best time. Along the way 1 · Along the way 2. Drive time is the route time for the mapped route without stops, from Mapbox.

Two-lane highway along the Minnesota shore of Lake Pepin.
US 61 follows the Mississippi south from Red Wing as a two-lane road to Wabasha, running along the Minnesota shore of Lake Pepin. It passes Frontenac State Park, Lake City, the largest town on the lake, and Reads Landing.
Best time to go: Open year round. Check 511 Minnesota road conditions in winter.

Sources: Best time. Along the way 1 · Along the way 2. Drive time is the route time for the mapped route without stops, from Mapbox.

Mostly two-lane highway following the St. Croix River past state parks.
Minnesota Highway 95, the St. Croix Trail, runs north from Stillwater parallel to the St. Croix River to Taylors Falls. Along this stretch it passes near William O'Brien State Park and reaches Interstate Park at Taylors Falls.
Best time to go: Open year round. Check 511 Minnesota road conditions in winter.

Sources: Length · Best time. Along the way 1 · Along the way 2. Drive time is the route time for the mapped route without stops, from Mapbox.

Follows Lake Superior's rocky North Shore, linking state parks and Split Rock Lighthouse. Duluth is about 2.5 to 3 hours from the Twin Cities, so make it a long day or a weekend.
The North Shore Scenic Drive leaves Duluth on County Road 61, the old shore road, then joins Highway 61 at Two Harbors and runs beside Lake Superior. It passes Gooseberry Falls State Park and Split Rock Lighthouse State Park, and the full byway continues to Grand Portage near the Canadian border.
Best time to go: Open year round. Check 511 Minnesota road conditions in winter.

Sources: Length · Best time. Along the way 1 · Along the way 2. Drive time is the route time for the mapped route without stops, from Mapbox.

County road past apple orchards, with access to Great River Bluffs State Park. La Crescent is about 2.5 to 3 hours from the Twin Cities, so make it a long day.
Apple Blossom Drive Scenic Byway runs 19 miles from La Crescent to US 61 north of Donehower, meeting the Great River Road at both ends. Many apple orchards line the route, and it gives access to Great River Bluffs State Park.
Best time to go: Open year round. Check 511 Minnesota road conditions in winter.

Sources: Length · Best time. Along the way. Drive time is the route time for the mapped route without stops, from Mapbox.
Open Road keeps every drive: the route on a map, the time and the distance. On iPhone and Android.